Given the unpredictable structure-activity relationship of this ribonucleoside liability, we propose a rapid and systematic in vitro screen combining cell-based and biochemical assays to identify the early potential They recommend ribavirin and ddI should be co-administered with caution, and ddI should be suspended if signs or symptoms suggestive of mitochondrial toxicity develop
Objective:To evaluate the incidence, clinical features, and risk factors for symptomatic mitochondrial
Increased risk of mitochondrial toxicity and lactic acidosis in HIV-positive patients taking nucleoside reverse transcriptase inhibitor (e
Drug-induced liver disease
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Inpharma Weekly
In a longitudinal analysis from January 2000 to July 2002, the researchers evaluated mitochondrial toxicity The combination of highly active antiretroviral therapy (HAART) plus ribavirin (RBV) in patients with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection has been reported to cause mitochondrial toxicity (MT)
Reactions Weekly volume 1062, page 5
Recent decades have seen a rapid increase in reported toxic effects of drugs and pollutants on mitochondria
Mitochondrial toxicity is recognized as a major adverse effect of nucleoside analogue treatment and can lead to myopathy, peripheral neuropathy, and hepatic steatosis with lactic acidosis, which can be life-threatening